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M94A2587.TXT
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Document 2587
DOCN M94A2587
TI In vitro and in vivo activities of sparfloxacin against Chlamydia
trachomatis.
DT 9412
AU Nakata K; Matsui T; Miyazaki S; Arakawa S; Ishigami J; Kamidono S; Kobe
University, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):270 (abstract no. PB0509). Unique
Identifier : AIDSLINE ICA10/94369988
AB OBJECTIVE: To test the in vitro and in vivo activity of sparfloxacin,
levofloxacin, tosufloxacin, clarithromycin and minocycline against C.
trachomatis. METHODS: The susceptibility of C. trachomatis (25 strains)
to sparfloxacin and the reference drugs was tested in vitro by
inhibiting inclusion body formations in McCoy cells. The vivo
antichlamydial activities of sparfloxacin and the reference drugs on C.
trachomatis KN infection were examined in experimental leukopenic mice.
Leukopenic mice were inoculated transurethrally with C. trachomatis, and
the drugs were given then orally twice a day for 3 days. On day 5 of
postinfection, the urinary bladder was removed and the mucous bladder
membranes were rubbed off with swabs which were then cultured with McCoy
cells. The absence of organisms in the urinary bladder was the sole
endpoint of therapeutic success. RESULTS: The MICs (microgram/ml) of
sparfloxacin, levofloxacin, tosufloxacin, clarithromycin, and
minocycline against 25 clinical isolates were 0.025-0.05, 0.25-0.5,
0.063-0.125, 0.025-0.05, and 0.025-0.05, respectively. The ED50s (mg/kg)
of sparfloxacin, levofloxacin, tosufloxacin, clarithromycin, and
minocycline on urinary tract infection with C. trachomatis KN were 3.4,
13.8, 13.6, 15.6, and 4.2, respectively. CONCLUSIONS: Based on results,
sparfloxacin is expected to be useful for treatment of C. trachomatis
infection in humans.
DE Animal Anti-Infective Agents, Fluoroquinolone/*PHARMACOLOGY Chlamydia
trachomatis/*DRUG EFFECTS Clarithromycin/PHARMACOLOGY Comparative
Study Dose-Response Relationship, Drug Mice Microbial Sensitivity
Tests Minocycline/PHARMACOLOGY Naphthyridines/PHARMACOLOGY
Quinolones/*PHARMACOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).